Neuroplasticity and Neurodegeneration

Research interest

  • Neuroanatomy of the olfactory system
  • Adult brain neurogenesis
  • Neuroanatomical changes in the human brain in Alzheimer’s and Parkinson’s diseases.
  • Transgenic models of Alzheime’rs and Parkinson’s diseases.
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Funding

  • Título: Alteraciones en los sistemas quimiosensoriales en las enfermedades de Alzheimer y Parkinson
    Entidad financiadora: Consejería de Educación, Cultura y Deportes
    I.P.: Alino Martínez Marcos
    Duración, desde: 27/09/2014   hasta: 26/09/2016
  • Título: Neurogénesis adulta: cambios hodológicos y alteraciones en modelos de las enfermedades de Alzheimer y Parkinson
    Entidad financiadora: Ministerio de Ciencia e Innovación
    I.P.: Alino Martínez Marcos
    Duración, desde: 01/01/2011   hasta: 31/12/2013
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Publications

  • De La Rosa-Prieto C, De Moya-Pinilla M, Saiz-Sanchez D, Ubeda-Banon I, Arzate DM, Flores-Cuadrado A, Liberia T, Crespo C, Martinez-Marcos A. Olfactory and cortical projections to bulbar and hippocampal adult-born neurons. Front Neuroanat. 2015 Feb 2;9:4. doi: 10.3389/fnana.2015.00004. eCollection 2015.. (A).
  • Saiz-Sanchez D, De la Rosa-Prieto C, Ubeda-Banon I, Martinez-Marcos A. Interneurons, tau and amyloid-? in the piriform cortex in Alzheimer’s disease. Brain Struct Funct. 2014 Apr 19. [Epub]. (A).
  • Ubeda-Bañon I, Saiz-Sanchez D, de la Rosa-Prieto C, Martinez-Marcos A. Alpha-Synuclein in the olfactory system in Parkinson’s disease: role of neural connections on spreading pathology. Brain Struct Funct. 2014;219(5):1513-26. doi: 10.1007/s00429-013-0651-2. [Epub 2013]. (A).
  • E Djibilian Fucci R, Pascual-Ramírez J, Martínez-Marcos A, Mantecón JM. Ultrasound-guided sciatic nerve pulsed radiofrequency for chronic knee pain treatment: a novel approach. J Anesth. 2013;27(6):935-8. (A).
  • Saiz-Sanchez D, De La Rosa-Prieto C, Ubeda-Bañon I, Martinez-Marcos A. Interneurons and Beta-Amyloid in the Olfactory Bulb, Anterior Olfactory Nucleus and Olfactory Tubercle in APPxPS1 Transgenic Mice Model of Alzheimer’s Disease. Anat Rec (Hoboken). 2013;296(9):1413-23. (A).
  • Mohedano-Moriano A, de la Rosa-Prieto C, Saiz-Sanchez D, Ubeda-Bañon I, Pro-Sistiaga P, de Moya-Pinilla M, Martinez-Marcos A. Centrifugal telencephalic afferent connections to the main and accessory olfactory bulbs.Front Neuroanat. 2012. 6: 19. (A).
  • Saiz-Sanchez D, Ubeda-Bañon I, De la Rosa-Prieto C, Martinez-Marcos A. Differential Expression of Interneuron Populations and Correlation with Amyloid-? Deposition in the Olfactory Cortex of an A?PP/PS1 Transgenic Mouse Model of Alzheimer’s Disease. J Alzheimers Dis. 2012. 31[1]: 113-129. (A).
  • Ubeda-Bañon I, Saiz-Sanchez D, de la Rosa-Prieto C, Martinez-Marcos A. ?-Synuclein in the olfactory system of a mouse model of Parkinson’s disease: correlation with olfactory projections. Brain Struct Funct. 2012. 217[2]: 447-458. [Epub 2011]. (A).
  • Saiz Sánchez D, de la Rosa Prieto C, Úbeda Bañón I, Martínez Marcos A. Neural basis of hyposmia in Alzheimer’s disease. En: The Clinical Spectrum of Alzheimer’s Disease -The Charge Toward Comprehensive Diagnostic and Therapeutic Strategies (de la Monte S, Ed). 2011. Págs: 347-362. ISBN: 978-953-307-993-6. Ed. Intech Open Access Publishers (Rijeka, Croacia). (CL).
  • de la Rosa-Prieto C, Saiz-Sánchez D, Ubeda-Bañón I, Mohedano-Moriano A, Martínez-Marcos A. Maturation of newly born vomeronasal neurons in the adult mice. Neurorreport. 2011. 22[1]: 28-32. (A).
  • Ubeda-Bañon I, Pro-Sistiaga P, Mohedano-Moriano A, Saiz-Sanchez D, de la Rosa-Prieto C, Gutierrez-Castellanos N, Lanuza E, Martinez-Garcia F, Martinez-Marcos A. Cladistic analysis of olfactory and vomeronasal systems.Front Neuroanat. 2011. 5: 3. (A).
  • Gutiérrez-Castellanos N, Martínez-Marcos A, Martínez-García F, Lanuza E. Chemosensory function of the amygdala. Vitam Horm. 2010. 83: 165-196. (A).
  • Saiz-Sanchez D, Úbeda-Bañón I, de la Rosa-Prieto C, Argandoña-Palacios L, García Muñozguren S, Insausti R, Martinez-Marcos A. The human olfactory system: an anatomical and cytoarchitectonic study of the anterior olfactory nucleus. (2010). Págs: 171-182. ISBN: 978-1-60741-610-4. Ed. Nova Publishers (Nueva York, EE.UU.). (CL).
  • Ubeda-Bañon I, Saiz-Sanchez D, de la Rosa-Prieto C, Mohedano-Moriano A, Fradejas N, Calvo S, Argandoña-Palacios L, Garcia-Muñozguren S, Martinez-Marcos A. Staging of alpha-synuclein in the olfactory bulb in a model of Parkinson’s disease: cell types involved. Mov Disord. 2010. 25[11]: 1701-1707. (A).
  • de la Rosa-Prieto C, Saiz-Sanchez D, Ubeda-Bañon I, Argandoña-Palacios L, Garcia-Muñozguren S, Martinez-Marcos A. Neurogenesis in subclasses of vomeronasal sensory neurons in adult mice. Dev Neurobiol. 2010. 70[14]: 961-970. (A).
  • Ubeda-Bañon I, Saiz-Sanchez D, de la Rosa-Prieto C, Argandoña-Palacios L, Garcia-Muñozguren S, Martinez-Marcos A. alpha-Synucleinopathy in the human olfactory system in Parkinson’s disease: involvement of calcium-binding protein- and substance P-positive cells. Acta Neuropathol. 2010. 119[6]: 723-735. (A).
  • Saiz-Sanchez D, Ubeda-Bañon I, de la Rosa-Prieto C, Argandoña-Palacios L, Garcia-Muñozguren S, Insausti R, Martinez-Marcos A. Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease. Exp Neurol. 2010. 223[2]: 347-350. [Epub 2009]. (A).
  • De La Rosa-Prieto C, Saiz-Sanchez D, Ubeda-Bañon I, Argandoña-Palacios L, Garcia-Muñozguren S, Martinez-Marcos A. Fate of marginal neuroblasts in the vomeronasal epithelium of adult mice. J Comp Neurol. 2009. 517[5]: 723-736. (A).
  • Martínez-Marcos A, Halpern M. Evolution of olfactory and vomeronasal systems. (2009). Págs: 1264-1269. ISBN: 978-3-540-23735-8. Ed. Springer Berlin Heidelberg (Berlin, Alemania). (CL).
  • Martínez-Marcos A. On the organization of olfactory and vomeronasal cortices. Prog Neurobiol. 2009. 87[1]: 21-30. [Epub 2008]. (R).
  • de la Rosa-Prieto C, Ubeda-Banon I, Mohedano-Moriano A, Pro-Sistiaga P, Saiz-Sanchez D, Insausti R, Martinez-Marcos A. Subicular and CA1 hippocampal projections to the accessory olfactory bulb. Hippocampus. 2009. 19[2]: 124-129. (A).
  • Ubeda-Bañon I, Novejarque A, Mohedano-Moriano A, Pro-Sistiaga P, Insausti R, Martinez-Garcia F, Lanuza E, Martinez-Marcos A. Vomeronasal inputs to the rodent ventral striatum. Brain Res Bull. 2008. 75[2-4]: 467-473. [Epub 2007]. (A).
  • Martínez-Marcos A. Apoptosis in the olfactory and vomeronasal systems. (2008). Págs: 155-166. ISBN: 1-60021-676-5. Ed. Nova Publishers (Hauppauge NY, EE.UU.). (CL).
  • Martínez-Marcos A. Neurogenesis in the olfactory and vomeronasal systems. (2008). Págs: 141-153. ISBN: 1-60021-676-5. Ed. Nova Publishers (Hauppauge NY, EE.UU.). (CL).
  • Mohedano-Moriano A, Pro-Sistiaga P, Ubeda-Bañon I, de la Rosa-Prieto C, Saiz-Sanchez D, Martinez-Marcos A. V1R and V2R segregated vomeronasal pathways to the hypothalamus. Neuroreport. 2008. 19[16]: 1623-1626. (A).
  • Pro-Sistiaga P, Mohedano-Moriano A, Ubeda-Bañon I, de la Rosa-Prieto C, Saiz-Sanchez D, Martinez-Marcos A.. Projections of olfactory bulbs to the olfactory and vomeronasal cortices. Neuroreport. 2008. 19[15]: 1541-1544. (A).
  • Ubeda-Bañon I, Novejarque A, Mohedano-Moriano A, Pro-Sistiaga P, de la Rosa-Prieto C, Insausti R, Martinez-Garcia F, Lanuza E, Martinez-Marcos A. Projections from the posterolateral olfactory amygdala to the ventral striatum: neural basis for reinforcing properties of chemical stimuli. BMC Neurosci. 2007. 8: 103. (A).
  • Pro-Sistiaga P, Mohedano-Moriano A, Ubeda-Banon I, Del Mar Arroyo-Jimenez M, Marcos P, Artacho-Perula E, Crespo C, Insausti R, Martinez-Marcos A. Convergence of olfactory and vomeronasal projections in the rat basal telencephalon. J Comp Neurol. 2007. 504[4]: 346-362. (A).
  • Mohedano-Moriano A, Pro-Sistiaga P, Ubeda-Banon I, Crespo C, Insausti R, Martinez-Marcos A. Segregated pathways to the vomeronasal amygdala: differential projections from the anterior and posterior divisions of the accessory olfactory bulb. Eur J Neurosci. 2007. 25[7]: 2065-2080. (A).
  • Anaya-Martinez V, Martinez-Marcos A, Martinez-Fong D, Aceves J, Erlij D. Substantia nigra compacta neurons that innervate the reticular thalamic nucleus in the rat also project to striatum or globus pallidus: implications for abnormal motor behavior. Neuroscience. 2006. 143[2]: 477-486. (A).
  • Úbeda I, Mohedado A, Pro P, Martínez-Marcos A. Nuevos aspectos sobre las proyecciones olfativas y vomeronasales. (2006). Págs: 97-109. ISBN: 84-933858-5-9. Ed. SBI, S.L. (Salqamanca, España). (CL).
  • Martinez-Marcos A, Halpern M. Efferent connections of the main olfactory bulb in the opossum (Monodelphis domestica): A characterization of the olfactory entorhinal cortex in a marsupial. Neurosci Lett. 2006. 395[1]: 51-56. [Epub 2005]. (A).

Alino Martínez Marcos

Director

People

Permanent staff

Phone: (+34) 926 295 300

Contact information

Facultad de Medicina de Ciudad Real

Universidad de Castilla-La Mancha

Avda. de Moledores, s/n

13071 Ciudad Real

telefono (+34) (+34) 926 295 300, ext. 6690

fax (+34) 902 204 130

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