Oxidative Stress and Neurodegeneration

Research interest

  1. Redox homeostasis and metabolic adaptation.
  2. Proteomics of adipose and nervous tissue.
  3. Role of somatostatin/cortistatin system and its receptors in neuroendocrine and cardiovascular disease.

grupo_estres

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Funding

  • Título: Papel del estrés oxidativo en el desarrollo de Ia ansiedad en el modelo murino de Alzheimer 3xTg-AD. Busqueda de marcadores tempranos de Ia neurodegeneracion
    Entidad financiadora: Consejería de Educación y Ciencia, JCCM
    I.P.: Francisco J. Alcaín Tejada
    Duración, desde: 27/09/2014   hasta: 26/09/2017
  • Título: Ayuda UCLM grupo Estrés oxidativo y neurodegeneración
    Entidad financiadora: Universidad de Castilla-La Mancha
    I.P.: Francisco J. Alcaín Tejada
    Duración, desde: 25/02/2015   hasta: 31/12/2015
  • Título: Animal estudy of the potential effect of ubiquinol
    Entidad financiadora: Kaneka Corp.
    I.P.: Francisco J. Alcaín Tejada
    Duración, desde: 24/05/2013   hasta: 30/04/2015
  • Título: Papel del COQ en el control del balance inflamatorio en el gliobastoma multiforme
    Entidad financiadora: Diputación de Ciudad Real
    I.P.: Mario Durán Prado
    Duración, desde: 04/07/2014   hasta: 31/01/2015
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Publications

  • Torres-Lista V, Parrado-Fernández C, Alvarez-Montón I, Frontiñán-Rubio J, Durán-Prado M2, Peinado JR, Johansson B, Alcaín FJ, Giménez-Llort L. Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice. Behav Brain Res. 2014;271:140-6. doi: 10.1016/j.bbr.2014.04.055. (A).
  • Peinado JR, Diaz-Ruiz A, Frühbeck G, Malagon MM. Mitochondria in metabolic disease: Getting clues from proteomic studies. Proteomics. 2014; 14(4-5):452-66. (A).
  • Martínez-González A, Durán-Prado M, Calvo GF, Alcaín FJ, Pérez-Romasanta LA, Pérez-García VM. Combined therapies of antithrombotics and antioxidants delay in silico brain tumour progression. Math Med Biol. 2014; [Epub]. (A).
  • Gahete MD, Durán-Prado M, Delgado-Niebla E, Garrido JJ, Rhodes SJ, García-Navarro S, Gracia-Navarro F, Malagón MM, Luque RM, Castaño JP. Porcine sst1 can physically interact with other somatostatin receptors, and its expression is regulated by metabolic/inflammatory sensors. Am J Physiol Endocrinol Metab. 2014;306(5):E483-93. [Epub 2013]. (A).
  • Malagón MM, Díaz-Ruiz A, Guzmán-Ruiz R, Jiménez-Gómez Y, Moreno NR, García-Navarro S, Vázquez-Martínez R, Peinado JR. Adipobiology for novel therapeutic approaches in metabolic syndrome. Curr Vasc Pharmacol. 2013; 11(6):954-67. [Epub 2012]. (A).
  • Peinado JR, Sami F, Rajpurohit N, Lindberg I. Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS. FEBS Lett. 2013;587(21):3406-11. (A).
  • López-Pelegrín M, Cerdà-Costa N, Martínez-Jiménez F, Cintas-Pedrola A, Canals A, Peinado JR, Marti-Renom MA, López-Otín C, Arolas JL, Gomis-Rüth FX. A novel family of soluble minimal scaffolds provides structural insight into the catalytic domains of integral membrane metallopeptidases. J Biol Chem. 2013; 288(29):21279-94. [Epub 2012]. (A).
  • Almabouada F, Diaz-Ruiz A, Rabanal-Ruiz Y, Peinado JR, Vazquez-Martinez R, Malagon MM. Adiponectin receptors form homomers and heteromers exhibiting distinct ligand binding and intracellular signaling properties. J Biol Chem. 2013; 288(5):3112-25. [Epub 2012]. (A).
  • Duran-Prado M, Morell M, Delgado-Maroto V, Castaño JP, Aneiros-Fernandez J, de Lecea L, Culler MD, Hernandez-Cortes P, O’Valle F, Delgado M. Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation. Circ Res. 2013;112(11):1444-55. (A).
  • Cruz-García D, Díaz-Ruiz A, Rabanal-Ruiz Y, Peinado JR, Gracia-Navarro F, Castaño JP, Montero-Hadjadje M, Tonon MC, Vaudry H, Anouar Y, Vázquez-Martínez R, Malagón MM. The Golgi-associated long coiled-coil protein NECC1 participates in the control of the regulated secretory pathway in PC12 cells. Biochem J. 2012;443(2):387-96. (A).
  • Durán-Prado M, Gahete MD, Delgado-Niebla E, Martínez-Fuentes AJ, Vázquez-Martínez R, García-Navarro S, Gracia-Navarro F, Malagon MM, Luque RM, Castaño JP. Truncated variants of pig somatostatin receptor subtype 5 (sst5) act as dominant-negative modulators for sst2-mediated signaling. Am J Physiol Endocrinol Metab. 2012;303(11):E1325-34. (A).
  • Bechtold-Dalla Pozza S, Hiedl S, Roeb J, Lohse P, Malik RE, Park S, Durán-Prado M, Rhodes SJ. A recessive mutation resulting in a disabling amino acid substitution (T194R) in the LHX3 homeodomain causes combined pituitary hormone deficiency. Horm Res Paediatr. 2012, 77[1]: 41-51. (A).
  • Villalba JM, de Cabo R, Alcain FJ. A patent review of sirtuin activators: an update. Expert Opin Ther Pat. 2012;22(4):355-367. (A).
  • Quirós PM, Ramsay AJ, Sala D, Fernández-Vizarra E, Rodríguez F, Peinado JR, Fernández-García MS, Vega JA, Enríquez JA, Zorzano A, López-Otín C. Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J. 2012; 31(9):2117-2133. (A).
  • Peinado JR, Pardo M, de la Rosa O, Malagón MM. Proteomic characterization of adipose tissue constituents, a necessary step for understanding adipose tissue complexity. Proteomics. 2012. 12[4-5]: 607-620. (A).
  • Duran-Prado M, Gahete MD, Hergueta-Redondo M, Martínez-Fuentes AJ, Córdoba-Chacón J, Palacios J, Gracia-Navarro F, Moreno-Bueno G, Malagón MM, Luque RM, Castaño JP. The new truncated somatostatin receptor variant sst5TMD4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells.Oncogene. 2012. 31[16]: 2049-2061. [Epub 2011]. (A).
  • Jódar L, Mercken EM, Ariza J, Younts C, González-Reyes JA, Alcaín FJ, Burón I, de Cabo R, Villalba JM. Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts. J Gerontol A Biol Sci Med Sci. 2011. 66[3]: 247-256. (A).
  • Domingo B, Gasset M, Durán-Prado M, Castaño JP, Serrano A, Fischer T, Llopis J. Discrimination between alternate membrane protein topologies in living cells using GFP/YFP tagging and pH exchange. Cell Mol Life Sci. 2010. 67[9]: 3345-3354. (A).

Francisco J. Alcaín Tejada

Director

People

Permanent staff
Other researchers

Phone: (+34) 926 295 300

Direcciones y teléfonos

Facultad de Medicina de Ciudad Real

Universidad de Castilla-La Mancha

Camino de Moledores s/n,

13071 Ciudad Real (España)

telefono (+34) 926 295300, Ext. 6638

fax (+34) 902 204 130

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